Can I use Moqups locally on my computer?

Moqups is exclusively online and browser based, so there's no downloadable, desktop version. However, you can export your project as an HTML version of the viewer that's perfect for presenting in offline environments.

Additionally, if you lose connectivity while working on project, you can keep editing for an hour or so. As long as you don't close your tab, your browser should be able sync once the connection is re-established.